AMS Fact Sheet – Menopause before 40 and spontaneous premature ovarian insufficiency

Menopause before 40 and spontaneous premature ovarian insufficiency (POI)

MAIN POINTS

• Premature ovarian insufficiency (POI) is a loss of function of the ovaries in women who are less than 40 years old.
• Spontaneous POI affects up to 4% of women less than 40 years and in most cases the cause is not identified.
• Irregular/no menstrual periods or menopausal symptoms may be the only sign of POI and blood tests are needed for diagnosis.
• POI can cause infertility and increase the risk of long-term health problems such as heart disease and osteoporosis.
• Hormone replacement therapy is recommended until the usual age of menopause (around 51 years) to reduce the long-term risks.
• Speak with your doctor about treatments and other options to manage any infertility and health consequences.